PHARM/PCS™Pharmacologic Calculation System

PHARM/PCS V5 · Procedure 42 Pairwise and Nonparametric

Chi-Square Test

Test whether two categorical variables are associated, from a contingency table of counts, with Yates' correction applied automatically to 2×2 tables.

What it computes

Tests whether observed frequencies differ significantly from expected (independence test). Enter each row of the contingency table as a group. For 2×2 tables, Yates' continuity correction is applied automatically.

Inputs and outputs

You provide

  • Each row of the contingency table, entered as a separate block of counts

PHARM/PCS reports

  • The chi-square statistic and degrees of freedom
  • An exact p-value and the verdict
  • A chart of observed against expected counts in each cell

When to use it

For counts, not measurements: testing whether two categorical variables are associated (a contingency table) or whether observed frequencies depart from expected. For confidence limits on a single proportion, use Procedure 43.

Reading the results

Chi-square is unreliable when expected cell counts are small (a common rule: watch out below about 5 per cell); with sparse tables an exact test is safer. Yates' continuity correction (a small adjustment that keeps the 2×2 test from overstating significance with discrete counts) is applied automatically; a significant result shows association but not its direction or strength, which you read from the table itself.

No chi-square table needed

V5 computes the chi-square distribution directly and reports an exact p-value, where the 1986 program compared the statistic against the book's Table A.8.

This page describes the procedure. Calculations run inside the licensed PHARM/PCS V5 application. PHARM/PCS is a trademark of MCS Scientific LLC.